May 2, 2008 - "Dead Jaw Syndrome" Linked to Osteoporosis Drugs
Microbial biofilms, a combination of bacteria and gelatinous extracellular material, are causing jaw tissue infections in patients taking osteoporosis drugs like Fosamax, Actonel and Boniva, according to a new research study conducted by the USC School of Dentistry. The same biofilms were linked earlier this year to eye infections caused by recalled Renu with MoistureLoc Contact Lens solutions.
Osteoporosis drugs are associated with a number of side effects, including Osteonecrosis of the Jaw (ONJ), also referred to as Dead Jaw Syndrome. ONJ prevents bone tissue in the jaw from healing after minor trauma such as when a tooth is extracted, causing the bone to be exposed. This can eventually lead to infection and fracture, often requiring long-term antibiotic therapy or surgery to extract the dying bone tissue.
In 2005, the warning labels on Fosamax and similar drugs were revised to include warnings about the risk of ONJ. The USC study indicates that ONJ occurs when biofilms containing high levels of bacteria infect the jaw after the bone is exposed as a result of a tooth extraction or other dental surgery.
The researchers used powerful scanning electron microscopes to study samples of patients’ jawbones. They found biofilm bacteria sprawling over pitted tissue. Researchers are now attempting to determine why osteoporosis drugs create a high risk for biofilm-associated infections of the jaw.
The information and materials on this Web site are provided for general informational purposes only and are not intended to be legal advice. We attempt to provide quality information, but the law changes frequently and varies from jurisdiction to jurisdiction. The information and materials provided are general in nature, and may not apply to a specific factual or legal circumstance. An attorney and client relationship should not be implied. Nothing on this Web site is intended to substitute for the advice of an attorney, therefore if you require legal advice please consult with a competent attorney licensed to practice in your jurisdiction. All attorneys, unless otherwise noted in website, are not certified by Texas Board of Legal Specialization. See Terms of Use.